Ondansetron HCl dihydrate is 5-HT3 receptor antagonist which is generally used for treatment of nausea and vomiting. This drug having low water solubility and low oral bioavailability (60%). Therefore, to provide this drug in a more accessible and patient compliant form and to overcome such problems, in the present study it was decided to formulation of rapid disintegrating tablet. On the basis of these considerations, in this study, effort has been made to formulate rapidly disintegrating tablet of Ondansetron hydrochloride using three superdisintegrants, Croscarmellose sodium, Crospovidone, SSG by using direct compression technology. Effect of different concentration of superdisintegrants on disintegration time of tablet and drug release was studied. The results concluded that poorly soluble drug Ondansetron hydrochloride dihydrate showing enhanced dissolution may lead to improved onset of action, bioavailability and patient compliance.
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